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Synergistic effects of cerebral small vessel disease burden and plasma phosphorylated tau 181 on white matter microstructure and cognition in a Chinese cohort 期刊论文

编号：

DBA188EB30553EF0AB159D5EFF95917C
作者：

Xu, Jingxian#^[1]Chen, HaoJie^[2,3,4,5];Wang, Yichen^[2,3,6,7];Hu, Zheqi^[1];Ke, Zhihong^[1];Huang, Lili(黄丽丽)^[1,8,9,10]Mo, Yuting^[1,8,9,10];Yang, Dan^[1];Mao, Chenglu^[1];Chen, Ying^[1];Zhu, Xiaolei(朱晓蕾)^[1,8,9,10]Chen, Haifeng(陈海峰)*^{[1,8,9,10,11]}Shu, Ni*^[2,3,6,7]Xu, Yun(徐运)*^{[1,8,9,10,11]}
语种：

英文
期刊：

BRAIN COMMUNICATIONS ISSN：2632-1297 2026 年 8 卷 2 期
收录：
关键词：

CSVD cognitive impairment plasma biomarker white matter synergistic effects
摘要：

Cerebral small vessel disease (CSVD) burden and plasma biomarkers are both critically associated with white matter (WM) microstructural damage and cognitive decline. However, whether these factors interact synergistically to exacerbate brain degeneration and cognitive decline remains unclear. We included 375 Chinese participants from the Aging cohort at Nanjing Drum Tower Hospital: 144 with no CSVD, 103 with mild CSVD (CSVD-I) and 128 with moderate to severe CSVD (CSVD-II). All participants underwent comprehensive cognitive assessment, plasma biomarker quantification and MRI scanning. Diffusion tensor imaging was used to evaluate WM microstructure. Interaction effects between CSVD burden and plasma biomarkers were analysed, and path analyses were performed to explore how two factors synergistically influence WM tracts and cognitive impairment. We found significant interactions between phosphorylated tau 181 (p-tau181) and CSVD burden on the integrity of multiple WM tracts (PFDR < 0.05). The CSVD-II showed the strongest effect of p-tau181 on neurofilament light, as well as an indirect effect of the cingulum mediating the relationship between p-tau181 and cognition [Delta IE & strns; = -0.108, 90% CI = (-0.25, -0.0302)]. Our findings suggest that vascular and molecular pathologies synergistically contribute to WM integrity damage and cognitive impairment. Targeting both vascular and molecular factors may be crucial for developing effective interventions to mitigate cognitive decline in the elderly population.
推荐引用方式
GB/T 7714：

Xu Jingxian,Chen Hao-Jie,Wang Yichen, et al. Synergistic effects of cerebral small vessel disease burden and plasma phosphorylated tau 181 on white matter microstructure and cognition in a Chinese cohort [J].BRAIN COMMUNICATIONS,2026,8(2).
APA：

Xu Jingxian,Chen Hao-Jie,Wang Yichen,Hu Zheqi,&Xu Yun.(2026).Synergistic effects of cerebral small vessel disease burden and plasma phosphorylated tau 181 on white matter microstructure and cognition in a Chinese cohort .BRAIN COMMUNICATIONS,8(2).
MLA：

Xu Jingxian, et al. "Synergistic effects of cerebral small vessel disease burden and plasma phosphorylated tau 181 on white matter microstructure and cognition in a Chinese cohort" .BRAIN COMMUNICATIONS 8,2(2026).
入库时间：

4/9/2026 10:19:05 PM
更新时间：

4/9/2026 10:19:05 PM

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