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Genomic characteristics and risk factor analysis of carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia in a tertiary hospital (2014-2023) 期刊论文

编号：

A40BC2DDEEB9A530220202E5825F725B
作者：

Zhai, Junbin^[1];Cao, Xiaoli(曹小利)^[1]Liu, Chang(刘畅)^[1]Zheng, Jie(郑洁)^[1]Zhang, Yan(张燕)^[1]Gao, Shuo(高硕)*^[1,2,3]Xu, Xuejing(徐学静)*^[1,2,3]
语种：

英文
期刊：

BMC MICROBIOLOGY ISSN：1471-2180 2026 年 26 卷 1 期 ; MAR 2
收录：
关键词：

Pseudomonas aeruginosa Bloodstream infections Carbapenem resistance OprD mutations Antimicrobial resistance Integron Mobile genetic elements Whole genome sequencing Risk factors
摘要：

Background Carbapenem-non-susceptible Pseudomonas aeruginosa (CnSPA) bloodstream infections (BSIs) are associated with high mortality and limited treatment options, yet long-term genomic-clinical data from China are scarce. Methods We retrospectively analyzed 52 non-duplicate CnSPA isolates causing BSIs from 2014 to 2023 in a tertiary hospital in eastern China. Whole-genome sequencing was used to characterize antimicrobial resistance genes (ARGs), carbapenem resistance-associated mutations, mobile genetic elements, sequence types (STs), serotypes, genetic relationship, and integron structures. Clinical data were integrated to identify risk factors for mortality and polymicrobial BSIs. Results CnSPA isolates showed high resistance to imipenem (98.1%) and multiple beta-lactams and fluoroquinolones, while remaining susceptible to colistin. Carbapenemase genes were rare, whereas diverse ARGs, frequent oprD and ampC mutations, and widespread co-localization of ARGs with insertion sequences supported a major role for non-carbapenemase mechanisms and mobile genetic elements in resistance dissemination. Thirty-six distinct STs-including high-risk clones ST235, ST244, ST274, and ST357, heterogeneous serotypes and phylogenetic tree indicated substantial genomic diversity. Integron analysis revealed structurally diverse complete integrons, CALINs, and In0 elements in a subset of genomes. Clinically, mortality was 38.5%; prior carbapenem exposure, organ failure, and prolonged mechanical ventilation were independent predictors of death, while long-term catheterization was associated with polymicrobial BSIs. Conclusions CnSPA BSIs in this setting are driven by multifactorial resistance mechanisms, high-risk clones, and mobile genetic elements, with modifiable clinical factors strongly linked to poor outcomes.
推荐引用方式
GB/T 7714：

Zhai Junbin,Cao Xiaoli,Liu Chang, et al. Genomic characteristics and risk factor analysis of carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia in a tertiary hospital (2014-2023) [J].BMC MICROBIOLOGY,2026,26(1).
APA：

Zhai Junbin,Cao Xiaoli,Liu Chang,Zheng Jie,&Xu Xuejing.(2026).Genomic characteristics and risk factor analysis of carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia in a tertiary hospital (2014-2023) .BMC MICROBIOLOGY,26(1).
MLA：

Zhai Junbin, et al. "Genomic characteristics and risk factor analysis of carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia in a tertiary hospital (2014-2023)" .BMC MICROBIOLOGY 26,1(2026).
入库时间：

4/23/2026 9:46:25 PM
更新时间：

4/23/2026 9:46:25 PM

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