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An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials 期刊论文

编号：

833A0DADB2B5B100C80D0280E454CB65
作者：

Huang, Chunyu#^[1,5]Zhao, Shukun^[2];Wu, Zhuhao(吴主昊)^[4]Zhu, Qian^[1];Zhou, Keying^[1];Wang, Miaomiao^[1];Li, Rui^[6];Cai, Bo*^[1]Zou, Danyi*^[3]Liu, Wei*^[2]Zhao, Xingzhong^[2];
语种：

英文
期刊：

JOURNAL OF ANALYSIS AND TESTING ISSN：2096-241X 2026 年 ; 2026 MAR 27
收录：
关键词：

Microfluidics Tumor spheroids Radiotherapy Nanomaterials Evaluation
摘要：

Abundant new nanomaterials are developed every year to enhance traditional radiotherapy by improving therapeutic response and reducing side effects. However, current pre-clinical models for evaluating these nanomaterials suffer from low fidelity (e.g., 2D cellular assays) or high cost (e.g., model animals). Considering that tumor spheroids can proliferate on a large scale and at low cost while possessing complex architectures that replicate in vivo solid tumors, in this work, we developed a microfluidic platform integrated with uniform tumor spheroids for the fast and reliable evaluation of radio-therapeutic nanomaterials. Utilizing a cascade of two microfluidic chips (G-chip and T-chip), our platform enabled fast generation, long-term cultivation, and precise pre-treatment of uniform tumor spheroids. The narrow size distribution and high viability of the tumor spheroids originating from the droplet microfluidic G-chip ensured the subsequent evaluation was reproducible and reliable. By regulating the concentration gradient formed in the T-chip through controlling fluidic flow rates, tumor spheroids can be pretreated with different concentrations of radio-therapeutic nanomaterials precisely and simultaneously. Herein, a previously reported radio-therapeutic nanoenzyme was employed to implement radiotherapy evaluation based on the platform as a proof of concept, producing results with high fidelity to in vivo solid tumor. This microfluidic platform shows great potential for the straightforward, reliable, and cost-effective evaluation of radiotherapy nanomaterials.
推荐引用方式
GB/T 7714：

Huang Chunyu,Zhao Shukun,Wu Zhuhao, et al. An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials [J].JOURNAL OF ANALYSIS AND TESTING,2026.
APA：

Huang Chunyu,Zhao Shukun,Wu Zhuhao,Zhu Qian,&Zhao Xingzhong.(2026).An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials .JOURNAL OF ANALYSIS AND TESTING.
MLA：

Huang Chunyu, et al. "An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials" .JOURNAL OF ANALYSIS AND TESTING(2026).
入库时间：

4/9/2026 10:19:13 PM
更新时间：

4/9/2026 10:19:13 PM

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