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Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: Protocol for a Multicenter Prospective Randomized Controlled Trial 期刊论文

编号：

73F06FB77ED1F057BC167DD78D75E14C
作者：

Xie, Qingyu#^[1,2,3]Peng, Rui^[1,2,3];Yue, Chao^[1,2,3];Wei, Wei^[1,2,3];Huang, Lingli^[1,2,3];Wang, Xiaoxiao^[4];Wang, Haitian^[1,2,3];Chen, Liang^[1,2,3];Gu, Rongmin^[1,2,3];Chen, Huanqiu^[1,2,3];Ming, Xuezhi^[1,2,3];Wen, Xu^[1,2,3];Xu, Weiguo^[1,2,3];Sun, Guangli^[1,2,3];Fan, Hao^[1,2,3];Wang, Zhe^[1,2,3];Yang, Longhao^[1,2,3];Zhou, Xiaohua^[5];Wu, Xiaoyu^[4];Zhou, Jin^[6];Wang, Meng^[7];Xu, Hao^[8];Li, Gang(李刚)*^[1,2,3]
语种：

英文
期刊：

JMIR RESEARCH PROTOCOLS ISSN：1929-0748 2026 年 15 卷
收录：
关键词：

gastric cancer proximal gastrectomy tunnel anastomosis double-tract jejunal interposition reconstruction antireflux
摘要：

Background: Tunnel anastomosis is a novel anastomotic technique for digestive tract reconstruction following proximal gastrectomy. A previous retrospective study by our team demonstrated its favorable antireflux effect; therefore, we hypothesize that tunnel anastomosis is noninferior to double-tract jejunal interposition reconstruction in preventing postoperative reflux esophagitis, and we will conduct this prospective study to further validate this assumption. Objective: In this study, we will prospectively compare tunnel anastomosis with the currently more prevalent double-tract jejunal interposition reconstruction technique to further validate its safety and efficacy. Methods: This is a multicenter prospective randomized controlled study that will enroll 240 patients who will undergo proximal gastrectomy. The study will be divided into 2 groups: the tunnel anastomosis group and the double-tract jejunal interposition reconstruction group, with 120 patients in each group. Patients will undergo clinical assessments and complete questionnaires preoperatively, as well as at the 3rd, 6th, and 12th months postoperatively. The primary end point is the incidence of reflux esophagitis within 1 year. The secondary end points include perioperative safety, postoperative quality of life, and postoperative nutritional status. Results: Recruitment of patients commenced in March 2022 and is scheduled to conclude in February 2027. The follow-up for all enrolled patients will be completed by February 2028. Conclusions: To our knowledge, this is the first prospective study on this technique, aiming to provide novel insights into the methods of digestive reconstruction following proximal gastrectomy. Trial Registration: Chinese Clinical Trial Registry ChiCTR2200057397; https://www.chictr.org.cn/showpro-jEN.html?proj=154418 International Registered Report Identifier (IRRID): DERR1-10.2196/82712
推荐引用方式
GB/T 7714：

Xie Qingyu,Peng Rui,Yue Chao, et al. Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: Protocol for a Multicenter Prospective Randomized Controlled Trial [J].JMIR RESEARCH PROTOCOLS,2026,15.
APA：

Xie Qingyu,Peng Rui,Yue Chao,Wei Wei,&Li Gang.(2026).Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: Protocol for a Multicenter Prospective Randomized Controlled Trial .JMIR RESEARCH PROTOCOLS,15.
MLA：

Xie Qingyu, et al. "Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: Protocol for a Multicenter Prospective Randomized Controlled Trial" .JMIR RESEARCH PROTOCOLS 15(2026).
入库时间：

4/30/2026 9:46:10 PM
更新时间：

4/30/2026 9:46:10 PM

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