Background Sepsis-induced liver injury (SILI) is a fatal complication of organ failure that currently lacks reliable biomarkers for early diagnosis and risk prediction. This study aimed to explore the link between the systemic immune-inflammatory index (SII) and SILI in adult patients with sepsis in the intensive care unit (ICU) at Nanjing Drum Tower Hospital. Methods This single-center retrospective study analyzed the baseline characteristics of patients with sepsis admitted to the ICU between 2020 and 2024. Multifactorial logistic regression was used to identify independent risk factors for SILI. Curve fitting and Subgroup analyzes were performed to provide evidence for the stratified management of patients with different clinical characteristics. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive capacity of the SII. Results A total of 231 patients were included, of whom 53 (22.9%) developed SILI during ICU hospitalization. Patients with SILI exhibited a significantly higher in-hospital mortality rate than non-SILI cases (52.8% vs. 25.3%, p < 0.001). Elevated SII at ICU admission was strongly associated with SILI development (p < 0.001). Multivariable logistic regression identified the SII as an independent risk factor for SILI. ROC curve analysis demonstrated that SII had superior predictive performance for SILI occurrence, with an area under the curve of 0.85 (95% CI: 0.784-0.907). Conclusion This retrospective study revealed a substantial association between high SII and SILI in adult ICU patients with sepsis, suggesting that SII is a promising indicator for post-sepsis SILI risk prediction.
[1]Nanjing Med Univ, Nanjing Drum Tower Hosp, Clin Coll, Nanjing, Peoples R China.
[2]Nanjing Univ, Affiliated Drum Tower Hosp, Dept Crit Care Med, Med Sch, Nanjing, Peoples R China.
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