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Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems 期刊论文

编号：

637B0214AC40D1F04E02834D3E7B1630
作者：

Xu, Hongtao#^[1]Liu, Rui^[2];Zhou, Hao^[1];Kong, Bin^[3];Shen, Kai^[1];Zhao, Tao^[4,5];Du, Xiaofeng^[6,7,8];Zhang, Hao^[9];Song, Huanghe^[1];Guo, Dunming^[1];Gu, Xiaoyuan^[1];Wang, Qing^[1];Lee, ChienWei^[10,11];Yin, Guoyong^[1];Zhang, Yingze^[6,7,8];Chen, Wei^[6,7,8];
语种：

英文
期刊：

BIOACTIVE MATERIALS ISSN：2452-199X 2026 年 59 卷 (96 - 134) ; MAY
收录：
关键词：

Extracellular vesicles Cargo loading Targeted delivery Therapeutic application
摘要：

Small extracellular vesicles (sEVs) are increasingly regarded as a unique class of bioactive materials whose intrinsic membrane composition and nanoscale architecture provide a versatile platform for therapeutic engineering. Rather than passive carriers, sEVs can be actively programmed through diverse strategies to achieve efficient loading, precise targeting, and functional integration with synthetic systems. Endogenous modulation of donor cells-via genetic editing, priming with bioactive glass, cytokine stimulation, or hypoxic cues-enables selective packaging of nucleic acids, proteins, and metabolites into secreted vesicles. Exogenous techniques, including electroporation, sonication, and extrusion, allow controlled incorporation of therapeutic drugs or genome-editing complexes such as CRISPR/Cas. In parallel, surface modifications based on Lamp2b-fusion scaffolds, aptamers, antibodies, and click chemistry confer tissue tropism and extend circulation time. Integration with nanomaterials, scaffolds, and microfluidic platforms further enhances stability, scalability, and reproducibility, positioning sEVs at the intersection of biology and materials science. This review highlights recent advances in engineering sEVs as programmable bioactive materials and discusses their potential to transform regenerative medicine, oncology, and precision therapeutics.
推荐引用方式
GB/T 7714：

Xu Hongtao,Liu Rui,Zhou Hao, et al. Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems [J].BIOACTIVE MATERIALS,2026,59:96-134.
APA：

Xu Hongtao,Liu Rui,Zhou Hao,Kong Bin,&Chen Wei.(2026).Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems .BIOACTIVE MATERIALS,59:96-134.
MLA：

Xu Hongtao, et al. "Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems" .BIOACTIVE MATERIALS 59(2026):96-134.
入库时间：

2/6/2026 3:34:51 PM
更新时间：

2/6/2026 3:34:51 PM

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