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A predictive 14-gene signature and FLI1 inhibition overcome tumor-infiltrating lymphocyte dysfunction in triple-negative breast cancer 期刊论文

编号：

5588780483F015FC210AE74AB0D05EB7
作者：

Jia, Meng#^[1]Jiang, Longwei^[1,2];Han, Siqi^[3,4];Zhang, Ying^[5];He, Juanjuan^[6];He, Guiyang^[6];Wu, Chong^[6];Zhang, Heng^[6];Liang, Hongwei(梁宏伟)^[6]Zen, Ke*^[1,9]Ao, Xudong*^[7,8,10]Jia, Shaochang*^[2,11]Liang, Junqing*^[7,8]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2026 年 823 卷 ; JUL 23
收录：
关键词：

Biomarkers Tumor infiltrating lymphocyte Breast cancer FLI1 TK216
摘要：

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Although immune checkpoint inhibitors such as pembrolizumab have improved clinical outcomes in a subset of patients, limited response rates and durability highlight the need for alternative strategies. Tumor-infiltrating lymphocyte (TIL)-based adoptive cell therapy represents a promising approach; however, the absence of reliable biomarkers for TIL functionality remains a major obstacle. In this study, we isolated TILs and autologous tumor cells from nine TNBC patients and classified TILs as reactive or non-reactive based on cytotoxic activity. Transcriptomic profiling combined with weighted gene co-expression network analysis and machine learning approaches identified a 14-gene signature that robustly distinguished reactive from non-reactive TILs. Transcription factor analysis revealed that Friend leukemia integration 1 (FLI1) regulates a large proportion of genes upregulated in non-reactive TILs. Notably, pharmacological inhibition of FLI1 using TK216 restored the cytotoxic function of non-reactive TILs and reduced expression of immunosuppressive genes. These findings identify a functional gene signature associated with TIL reactivity and suggest that targeting FLI1 may represent a strategy to enhance TILbased immunotherapy in TNBC.
推荐引用方式
GB/T 7714：

Jia Meng,Jiang Longwei,Han Siqi, et al. A predictive 14-gene signature and FLI1 inhibition overcome tumor-infiltrating lymphocyte dysfunction in triple-negative breast cancer [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2026,823.
APA：

Jia Meng,Jiang Longwei,Han Siqi,Zhang Ying,&Liang Junqing.(2026).A predictive 14-gene signature and FLI1 inhibition overcome tumor-infiltrating lymphocyte dysfunction in triple-negative breast cancer .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,823.
MLA：

Jia Meng, et al. "A predictive 14-gene signature and FLI1 inhibition overcome tumor-infiltrating lymphocyte dysfunction in triple-negative breast cancer" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 823(2026).
入库时间：

6/1/2026 2:00:34 PM
更新时间：

6/1/2026 2:00:34 PM

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