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Molecular heterogeneity of the non-human primate cochlea 期刊论文

编号：

4BF8F3F2AC910D2FA7C18B2C08B9BC9A
作者：

Chen, Xin#^[1,2]Che, Yuwei^[1];Qi, Jieyu^[3,4];Cen, Ming^[1];Gao, Shan^[1];Zhu, Bin^[1];Ao, Yiheng^[1];Ma, Xiangyu^[1];Cheng, Cheng(程诚)^[5,6]Guo, Rongrong^[7,8];Wang, Xinlin^[1];Shen, Tian^[9];Wu, Jiheng^[1];Kong, Fanliang^[1];Si, Wei^[7,8];Chen, Yongchang^[7,8];Tan, Tao^[7,8];Lu, Ling*^[1]Chai, Renjie*^{[1,2,3,10,11]}
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2026 年 17 卷 1 期 ; JAN 17
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摘要：

Unraveling the intricate composition and function of the cochlea is paramount to comprehending the mechanisms underlying sound perception and the pathogenesis of auditory disorders. The mammalian cochlea displays a highly organized structure, which contributes to the diversity and complexity of auditory processing. However, the cellular intricacies in non-human primates remain largely unexplored. In the present study, we employed high-throughput transcriptomic sequencing to profile over 36,701 nuclei across virtually all cochlear cell types in both juvenile and adult Macaca fascicularis at single-cell resolution. Our analysis unveiled remarkable heterogeneity both across and within cell types. Despite a largely conserved cellular composition of the cochlea between mouse and macaque species, glial cells exhibited substantial species-specific diversity, while hair cells and spiral ganglion neurons with specialized transcriptional programs were well-mapped onto their murine counterparts, underscoring the similarities that persist despite evolutionary divergence. Furthermore, we constructed a disease map associated with hearing loss, establishing this transcriptomic atlas of the macaque cochlea as an indispensable resource for future investigations in both human and non-human primates.
推荐引用方式
GB/T 7714：

Chen Xin,Che Yuwei,Qi Jieyu, et al. Molecular heterogeneity of the non-human primate cochlea [J].NATURE COMMUNICATIONS,2026,17(1).
APA：

Chen Xin,Che Yuwei,Qi Jieyu,Cen Ming,&Chai Renjie.(2026).Molecular heterogeneity of the non-human primate cochlea .NATURE COMMUNICATIONS,17(1).
MLA：

Chen Xin, et al. "Molecular heterogeneity of the non-human primate cochlea" .NATURE COMMUNICATIONS 17,1(2026).
入库时间：

3/2/2026 9:54:32 AM
更新时间：

3/2/2026 9:54:32 AM

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